microbiome in reflux disorders and esophageal adenocarcinoma pdf

Microbiome In Reflux Disorders And Esophageal Adenocarcinoma Pdf

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Cancer Journal Sudbury, Mass.

The incidence of esophageal adenocarcinoma has increased dramatically in the United States and Europe since the s without apparent cause. Although specific host factors can affect risk of disease, such a rapid increase in incidence must be predominantly environmental. In the stomach, infection with Helicobacter pylori has been linked to chronic atrophic gastritis, an inflammatory precursor of gastric adenocarcinoma.

Signatures within the esophageal microbiome are associated with host genetics, age, and disease

While intestinal microbiomes have been relatively well studied, upper gastrointestinal tract microbiomes have not been thoroughly evaluated. Especially, studies on esophageal microbiomes are relatively limited. Traditionally, the esophagus is regarded as devoid of a significant bacterial population. However, next-generation sequencing techniques such as 16S ribosomal RNA rRNA gene sequencing have been increasingly used to open a new horizon for microbial research nowadays. Appendix 1 shows the detailed search strategies in each database. The inclusion criteria were as follows: 1 healthy individuals or patients with esophageal diseases including GERD, esophageal cancer, EoE, and achalasia, and 2 composition or any other findings about the esophageal microbiome. Non-original studies, non-human studies, abstract-only publications, and studies published in languages other than English were excluded.

Microbiome and Gastroesophageal Disease: Pathogenesis and Implications for Therapy

Ann Clin Gastroenterol Hepatol. DOI: ORCiD: orcid. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. FullText PDF.

Microbiome in reflux disorders and esophageal adenocarcinoma.

Metrics details. The esophageal microbiome has been proposed to be involved in a range of diseases including the esophageal adenocarcinoma cascade; however, little is currently known about its function and relationship to the host. Here, the esophageal microbiomes of prospectively recruited patients were assessed using 16S rRNA and 18S rRNA amplicon sequencing as well as shotgun sequencing, and associations with age, gender, proton pump inhibitor use, host genetics, and disease were tested.

We explored the potential signature of esophageal microbiota and its predicted functional profile along the continuous spectrum from BE to EAC. We analyzed through 16S-based amplicon sequencing the mucosal microbiota and the microbiota-related functional predictions in 10 BE and 6 EAC patients compared with 10 controls, exploring also potential differences between the metaplastic mucosa BEM and the adjacent normal areas of BE patients BEU. Functional predictions identified peculiar profiles for each group with a high potential for replication and repair in BEM; an upregulated energy, replication and signaling metabolisms, with the fatty-acids biosynthesis and nitrogen and D-alanine pathways down-regulated in EAC.

Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include gastroesophageal reflux GER , male sex, older age, central obesity, tobacco smoking, Helicobacter pylori H. The human gut harbors trillions of microorganisms, the majority of which are bacteria. These microorganisms benefit the human host in many ways, such as helping in digestion, assisting in the synthesis of certain vitamins, promoting the development of the gastrointestinal immune system, regulating metabolism and preventing invasion by specific pathogens.

Microbiome in Reflux Disorders and Esophageal Adenocarcinoma

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