immunoglobulin gene mutation patterns and heterogeneity of marginal zone lymphoma pdf

Immunoglobulin Gene Mutation Patterns And Heterogeneity Of Marginal Zone Lymphoma Pdf

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Marginal zone B-cell lymphoma

Lebien , Fates of human 8-cell precursors , Blood , vol. Schwickert , ln vivo imaging of germinal centres reveals a dynamic open structure , Nature , issue. Lebien and T. DOI : Gardembas, M. Foussard, C. Gardais, J.

The clonotypic B cell receptor immunoglobulin BcR IG plays a seminal role in B cell lymphoma development and evolution. This clinical development complements immunogenetic evidence for antigen drive in the natural history of these tumors. Moreover, distinct entities display imprints of somatic hypermutation within the clonotypic BcR IG gene following patterns that strengthen the argument for antigen selection. Of note, at least in certain B cell lymphomas, the BcR IG genes are intraclonally diversified, likely in a context of ongoing interactions with antigen s. Moreover, BcR IG gene repertoire profiling suggests that unique immune pathways lead to distinct B cell lymphomas through targeting cells at different stages in the B cell differentiation trajectory e.

The considerable heterogeneity in morphology, immunophenotype, genotype, and clinical behavior of splenic marginal zone lymphoma SMZL hinders firm conclusions on the origin and differentiation stage of the neoplastic cells. These results provide evidence for the diverse B-cell subpopulations residing in the SMZ, which could represent physiologic equivalents of distinct SMZL subtypes. The marginal zone of the human spleen SMZ is a microanatomical site at the border of the white and red pulp, mainly comprising of B cells, T cells, and macrophages. The SMZ appears especially well equipped for rapid humoral immune responses to blood-borne antigens. There is considerable evidence suggesting that responses to thymus independent type 2 antigens for example, bacterial capsular polysaccharides are dependent on the normal function of the splenic marginal zone 1 — 3.

Immunoglobulin Heavy-And Light-chain Repertoire in Splenic Marginal Zone Lymphoma

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases show immunoglobulin gene mutations, half of which show evidence of antigen selection, whereas one-third of the cases show no significant mutations. No statistical significant correlation was found between immunoglobulin mutation status and clinical, immunophenotypic, or genetic characteristics. Our results demonstrate that on-going somatic hypermutation is a prominent feature of splenic marginal zone lymphoma with circulating villous lymphocytes.

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Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection. Three cases out of 18 with clones analyzed from spleen and peripheral blood demonstrated intra-clonal diversity, with evidence of clonal selection in one case, indicating the possibility of antigen-driven clonal expansion. No differences in clinical outcome and overall survival were found between the unmutated and mutated cases. Moreover, a biased usage of certain sequences suggests that tumor cells in SMZL may be subjected to antigen selection. Article Information Vol.

The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma NMZL remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples and the technical approach to analyze the immunoglobulin genes was of amplifying rearranged variable region genes with the classical direct sequencing of the PCR products followed by cloning. We analyzed the mutational pattern to detect and quantify antigen selection pressure and we found a positive selection in 4 cases, whereas in the remaining cases there was an unspecific stimulation.

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The considerable heterogeneity in morphology, immunophenotype, genotype, and clinical behavior of splenic marginal zone lymphoma SMZL hinders firm conclusions on the origin and differentiation stage of the neoplastic cells. These results provide evidence for the diverse B-cell subpopulations residing in the SMZ, which could represent physiologic equivalents of distinct SMZL subtypes. Tags Type your tag names separated by a space and hit enter. Mol Med. Belessi C. Papadaki T.

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.

Blood ; 10 : — Nodal marginal zone lymphoma NMZL is a rare, indolent B-cell tumor that is distinguished from splenic marginal zone lymphoma SMZL by the different pattern of dissemination. NMZL still lacks distinct markers and remains orphan of specific cancer gene lesions. By combining whole-exome sequencing, targeted sequencing of tumor-related genes, whole-transcriptome sequencing, and high-resolution single nucleotide polymorphism array analysis, we aimed at disclosing the pathways that are molecularly deregulated in NMZL and we compare the molecular profile of NMZL with that of SMZL. These analyses identified a distinctive pattern of nonsilent somatic lesions in NMZL.

AIM : To investigate how t 11;18 q21;q21 -positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the V H genes and the expression of the marker CD All cases were immunostained for CD These data suggest that the translocation t 11;18 q21;q21 can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation.

Marginal zone B-cell lymphomas , also known as marginal zone lymphomas MZLs , are a heterogeneous group of lymphomas that derive from the malignant transformation of marginal zone B-cells. MALT , the spleen , or lymph nodes. Mucosa-associated lymphoid tissue is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body such as the gastrointestinal tract , mouth , nasal cavity , pharynx , thyroid gland , breast , lung , salivary glands , eye , skin and the human spleen.

 - Внезапно Беккер понял, что говорит чересчур громко. Люди на соседних койках приподнялись и внимательно наблюдали за происходящим.

 Двадцать миллионов американских долларов. Почти столько же поставил Нуматака. - Двадцать миллионов? - повторил он с притворным ужасом.  - Это уму непостижимо. - Я видел алгоритм.

В Севильском соборе единственный вход одновременно является выходом. Такая архитектура стала популярной в те времена, когда церкви одновременно служили и крепостями, защищавшими от вторжения мавров, поскольку одну дверь легче забаррикадировать. Теперь у нее была другая функция: любой турист, входящий в собор, должен купить билет. Дверь высотой в шесть метров закрылась с гулким стуком, и Беккер оказался заперт в Божьем доме.

Теперь он был на виду, его голова торчала из оконного проема как на гильотине. Беккер подтянул ноги, стараясь протиснуться в проем. Когда его торс уже свисал над лестницей, шаги послышались совсем. Он схватился руками за боковые стороны проема и, одним движением вбросив свое тело внутрь, тяжело рухнул на лестницу. Халохот услышал, как где-то ниже тело Беккера упало на каменные ступеньки, и бросился вниз, сжимая в руке пистолет.

Но, ожив, монитор вновь показал то же. Чатрукьяну вдруг стало холодно. У сотрудников лаборатории систем безопасности была единственная обязанность - поддерживать ТРАНСТЕКСТ в чистоте, следить, чтобы в него не проникли вирусы. Он знал, что пятнадцатичасовой прогон может означать только одно: зараженный файл попал в компьютер и выводит из строя программу.

 - Это ведь хорошо, правда. - Нет! - взорвался Джабба.  - Это плохо.

Внезапно она вспомнила, зачем искала Стратмора, и повернулась к. - Коммандер. Северная Дакота - это Грег Хейл.

Все эти десять лет, в штиль и в бурю, он вел ее за .

 - Он привлек внимание к тексту на экране.  - Кто-нибудь может мне объяснить, что это. ВАС МОЖЕТ СПАСТИ ТОЛЬКО ПРАВДА ВВЕДИТЕ КЛЮЧ______ Джабба не дождался ответа.

А потом этот парень умер. - А вы пробовали сделать ему искусственное дыхание? - предположил Беккер. - Нет. Мы к нему не прикасались.

Здесь есть браузер. Соши кивнула. - Лучше всего - Нетскейп. Сьюзан сжала ее руку.

 Дэвид Беккер.  - Он пожал ее руку.

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